NIHR/Wellcome Trust Imperial Clinical Research Facility is happy to share the news that our LSD-fMRI/MEG study has been recently published in Proceedings of the National Academy of Sciences (PNAS). The paper reveals the findings from the healthy volunteer study that ran in our facility in 2013. The aim of this study was to use fMRI to investigate the effects of LSD on brain activity in 20 healthy hallucinogen-experienced volunteers.
The results of the single blind placebo-controlled study revealed that there were marked changes in brain blood flow, electrical activity, and network communication patterns that correlated strongly with the drug’s hallucinatory and other consciousness-altering properties. The teams hope these collective findings may pave the way for these compounds being one day used to treat psychiatric disorders. They could be particularly useful in conditions where negative thought patterns have become entrenched, say the scientists, such as in depression or addiction.
Dr Robin Carhart-Harris, from the Department of Medicine at Imperial, who led the research, explained: “We observed brain changes under LSD that suggested our volunteers were ‘seeing with their eyes shut’ – albeit they were seeing things from their imagination rather than from the outside world”.
Several media outlets have been sharing the results of the LSD study that was conducted at Imperial Clinical Research Facility. You can find the article from Imperial College London news page here or the Guardian science page here.Imperial CRF’s LSD Study Published