This study was published in 2009 in the Clinical Gastroenterology and Hepatology Journal.
Chronic diarrhoea due to bile acids is common, affecting 1% of the population. Our work has shown that deficiency of FGF19, produced by the ileum, has a major role in causing this primary bile acid diarrhoea. Studies of patients in the CRF have looked at how FGF19 changes in these patients in response to meals, to see whether it can be stimulated or whether it remains low. Different phenotypes have been identified and related to genetic differences which may help predict response to therapy. We are about to embark on a pilot proof-of-concept study in patients of a new drug that will stimulate FGF19 production.
PI: Professor Julian Walters