GHADD

Name of Study:

Gut Hormones in Addiction (GHADD)

What does the study involve?

We are investigating the effects certain gut hormones (hormones that are produced in the stomach and intestine) have on eating and addictive behaviours in people who are overweight, or have recently stopped smoking or drinking alcohol (or planning to do so in the near future). Previous studies have shown that these gut hormones not only control our appetite and food intake, but may also alter the craving for alcohol and drugs.

We are interested in how these hormones affect brain functioning in people that have recently given up alcohol or cigarettes. This could give us important information about how the hormones affect relapse to alcohol and cigarettes, and have the additional benefits of preventing weight gain.

We will investigate the effects of these hormones through their infusion via a cannula in your arm while you undergo an MRI scan and do some simple computer tasks. You will also complete some questionnaires and have blood taken.These hormones have been used in many medical research studies before and are safe.

The GHADD study is funded by the Medical Research Council (MRC) of the United Kingdom and will take place at the Hammersmith Hospital at Imperial College London. The GHADD study has been ethically approved by the London-Central Research Ethics Committee: 15/LO/1041.

You will receive payment for your time and travel expenses if you are eligible and decide to participate in the GHADD study.

What is involved?

If you decide that you would like to take part we will contact you by phone for a telephone screening to make sure you are eligible. If you are, you will need to come for a screening visit. All visits will take place at the NIHR/Wellcome Trust Imperial Clinical Research Facility and the Imanova Centre for Imaging Sciences, at the Hammersmith Hospital (White City).

Who are we looking for?

  • Are you 18-60 years of age?
  • Are you either:
    • an alcoholic who has recently quit drinking (6 weeks to 12 months ago, or planning to do so in the near future)?
    • a cigarette smoker who has recently quit smoking (6 weeks to 12 months ago, or planning to do so in the near future)?
    • overweight or obese and do NOT have a history of alchohol, tobacco or substance dependence?
  • Are you able to read, speak and understand spoken and written English?
  • Are you willing to complete 4 separate visits to the Hammersmith Hospital over approximately 6 weeks? 

Answered yes to these questions? Then you might qualify! But please read on.

  • Have you ever had:
    • a stroke?
    • a heart attack?
    • diabetes?
    • pancreatitis (inflammation of the pancreas)?
  • Do you have a pacemaker?
  • Are you claustrophobic (uncomfortable in small spaces)?
  • Are you a vegetarian/vegan/gluten- or lactose-intolerant?

Answered yes to any of these questions? Then unfortunately you cannot take part.

How can I find out more?

Website: www.ghadd.co.uk
Or send email to ghadd@imperial.ac.uk
Or call 020 7594 6648 or 020 7594 8586.

GHADD