This study was published in December 2014 in the journal Gut.
In this study, we are investigating the effect of sodium propionate on pancreatic beta cell and to determine its impact on diabetes risk. This study comprises of 3 phases. Phase 1 is the pharmacokinetic study with the aim of measuring time to peak plasma concentration of orally administered sodium propionate in healthy volunteers. Phase 2 is the dose finding study to determine the most efficacious dose of sodium propionate on beta cell function in healthy volunteers using oral glucose tolerance tests. Phase 3 of the study is to determine how sodium propionate improves glucose tolerance. We will determine the mode of action of sodium propionate on improving glucose tolerance by performing acute intravenous glucose tolerance tests in both healthy volunteers and healthy volunteers at risk of developing diabetes. We are currently recruiting volunteers for Phase 2 of the study.Propionate (Published)