iPREVENT Study

Overweight and obesity affects over 60% of the UK population. In adults, most weight gain occurs when people are in their 20s and 30s and causes many adults to become obese by the time they are middle-aged, leading to increased risk of developing diabetes, heart disease and cancer.

The amount of fibre (found in edible plant foods such as cereals, fruits, vegetables, nuts, lentils and grains) eaten in the diet has been linked to body weight.  People who eat low amounts of dietary fibre are more likely to gain weight.

We know that dietary fibre keeps the bacteria in our gut healthy. These bacteria break down dietary fibre to short chain fatty acids (smaller pieces of fibre) which can reduce appetite and body fat. ‘Propionate’ it thought to be the best at reducing appetite.

The iPREVENT study is looking at whether a new dietary supplement called Inulin Propionate Ester (IPE) can help with prevention of weight gain.

We are looking for adults aged 20-40 years with a BMI of 25-30 (or 24-27 if you are of South Asian origin), and at least one of the following:

  • Weight gain in the past 12 months
  • Less than 2 portions of fruit/veg per day
  • Regular sugary drinks
  • Little or no exercise

Participants will be asked to take the supplement once a day for 12 months. There will be a screening visit plus 4 study visits across 12 months. This will involve having body and weight measurements taken, and routine blood tests.

Participants will be entitled to £50 per study visit (£200 in total) as well as travel expenses, to compensate for their time and support.

The study is being run by Imperial College London and University of Glasgow. For further information, contact us London – imperial.iprevent@nhs.net or call/text 07951 686783; Glasgow – georgethom1@nhs.net or call/text 07483 805691

iPREVENT Study