Upper GI Appetite Study

Overweight and obesity affects over 60% of the UK population. It is caused by chronic surplus of energy intake relative to energy output. Appetite is regulated by a complex combination of external and internal factors, and there is evidence that this is dysregulated in obese people.

Meals containing the same energy, but rich in sugar, protein or fats, also have different effects on fullness. Obese people sense nutrients differently to those of a healthy weight, meaning they do not feel as full after a meal. However, the reasons for this are unknown.

We are investigating how healthy weight and obese people digest and absorb meals rich in different nutrients, and how this affects their fullness. We require participants who:

  • Are between 18 and 60 years old
  • Are healthy
  • Have a BMI of 18.5-24.9kg/m2 or 30-39.9kg/m2

Participants will attend the Clinical Research Facility on one day for a screening visit, followed by a separate four-day stay during which time the study will take place.

During the study, participants will have nasal tubes inserted that will lie in the stomach and the first part of the small intestine. They will drink a milkshake high in either sugar, protein or fat. Gut contents will be collected from these tubes to monitor digestion and absorption of the meal. Blood samples will also be taken, and participants will also complete questionnaires assessing their feelings of fullness. This will help us understand how nutrients are sensed in the gut and the blood stream to regulate food intake, and provide insight into how to design diets to combat obesity.

As compensation for their time and inconvenience, participants will receive £10 for the screening visit and £400 for the main visit, plus travel expenses.

For further information, please contact us:

Email: metab.macro@imperial.ac.uk Telephone: 07494699830

This study has been approved by the South West – Frenchay Research Ethics Committee, reference 19/SW/0023.

Upper GI Appetite Study